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A nurse is caring for a client diagnosed with testicular cancer who is receiving cisplatin intravenously. The nurse monitors the client for drug-drug interaction if which among the following are administered?

Explanation

•Cisplatin increases methotrexate toxicity.

•Cisplatin decreases the effect of Phenytoin.

•Cisplatin administered with Bumetanide increases ototoxicity.

•There is no reported drug-drug interaction between cisplatin and acetaminophen.

•Loop Diuretics may enhance the ototoxic and nephrotoxic effects of cisplatin

•There is no reported drug-drug interaction between cisplatin and Meperidine.

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