A patient has a history of severe allergic reaction to glipizide.  A nurse would also expect a reaction to which of the following medications?

Hydrochlorothiazide
Mafenide
Sulfasalazine
Trimethoprim/sulfamethoxazole

Explanation

•Glipizide (Glucotrol) is a sulfa-containing medication for type 2 diabetes. Sulfa allergies are common and all sulfa-containing medications and drug combinations can potentially cause allergic reactions. However, sulfa based antibiotics are the most common source of allergic reactions for patients.

•Mafenide and hydrochlorathiazide both also contain sulfa. The use of these medications should be avoided because of the severe allergic reaction to glipizide.

•Linezolid and Cefazolin are non-sulfa containing antibiotics. Linezolid is a oxazolidinone and Cefazolin is a cephalosporin. Cephalosporins are penicillin containing antibiotics.

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