A patient is prescribed micronized estradiol for the treatment of perimenopausal symptoms. The nurse should inform this patient that this medication increases the risk of:

Endometrial cancer
Stroke

Explanation

•Estrogen therapy unopposed by progestin increases the risk for endometrial cancer, heart disease, stroke, and thromboembolic events.  Ovarian and breast cancer risks are also increased.

•Estrogen therapy has not been shown to increase the risk for liver cancer, lung cancer, or leukemia.

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