A patient taking duloxetine for depression is receiving instructions regarding possible adverse reactions to the drug. In some situations, routine blood tests may be necessary. The nurse informs the patient that the blood tests are for monitoring

Liver function.


• Duloxetine (Cymbalta), an SNRI, has been shown to increase serum liver enzymes and cause liver toxicity.

• Duloxetine is used to treat depression, fibromyalgia, and generalized anxiety disorder.

• Side effects of SNRIs are similar to SSRIs and discontinuation should be gradual.

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