A patient with diabetes taking acarbose should be assessed for which potential adverse reaction?

Elevated alanine aminotransferase (ALT)
Elevated aspartate aminotransferase (AST)


•Acarbose has been shown to cause liver damage, leading to an elevation of serum transaminases (AST and ALT).

•Acarbose inhibits alpha-glucosidase, an enzyme needed to digest complex carbohydrates in the gut.

•Acarbose and all other alpha-glucosidase inhibitors do not normally cause hypoglycemia.

•Acarbose is not associated with elevated creatinine or anemia.

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