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A patient with severe sepsis is at risk for pseudomembranous colitis when taking which of the follow medications?

Explanation

•The use of clindamycin, cephalosporins, penicillins, and other antibiotics can result in the destruction of the normal flora of the intestines. This provides an opportunity for C. difficile to grow, causing pseudomembranous colitis.

•Clindamycin has a black box warning for its high occurrence of pseudomembranous colitis.

•Miconazole, an antifungal, does not destroy the normal flora of the intestines.

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