A patient with tuberculosis is prescribed rifampin as part of a multi-drug regimen. Which of the following is true about rifampin?


• Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible cells.

• Rifampin is a tuberculocidal agent that is used to treat active or latent tuberculosis infections. It also treats asymptomatic meningococcal carriers, endocarditis, and Hansen disease (leprosy).

• Rifampin has a large number of drug-to-drug interactions.

• Rifampin may cause a harmless and temporary reddish discoloration of urine, sweat, saliva, or tears.

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