Explanation
•In Von Willebrand’s disease, the body has a deficiency of von Willebrand factor (vWF). vWF helps release factor VIII and in its absence, factor VIII degrades, causing a prolonged aPTT and decreased platelet adhesion.
•Von Willebrand disease is the most common hereditary coagulation abnormality but it can also be aquired.
•A prolonged PT and increased INR occurs with a vitamin K deficiency or coumadin therapy.
•Increased platelet count may occur due to a malignancy or inflammation.