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A 60-year old woman was diagnosed with breast cancer and has been treated for 5 years. She is considered at high risk for recurrence but currently shows no evidence of the disease. She is a candidate for adjuvant chemotherapy. Which among the following are chemotherapeutic agents?

Explanation

•Misoprostol suppresses secretion of gastric acid and stimulates production of cytoprotective mucus & is considered a hyposecretory agent.

•Methotrexate is an antimetabolite developed as a folic acid analogue that inhibits purine and pyrimidine synthesis, accounting for its efficacy in the therapy of cancer and rheumatoid arthritis.

•Nitroprusside sodium is an antihypertensive and vasodilator.

•Vincristine is a Vinca alkaloid with its antitumor activity thought to be due primarily to inhibition of mitosis at metaphase through its interaciton with tubulin.

•Sotalol is a beta-adrenergic blocking agent, commonly used for cardiac disorders.

•Tamoxifen is an antiestrogen, chemotherapeutic nonsteroidal agent that binds to estrogen receptors, inducing a conformational change in the receptor and is indicated for the treatment of metastatic breast cancer and ductal carcinoma in Situ.

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