A nurse is caring for a client diagnosed with testicular cancer who is receiving Cisplatin intravenously. The nurse monitors the client for a drug-drug interaction if which among the following are also administered?

Explanation

• Cisplatin increases methotrexate toxicity.

• Cisplatin decreases the effect of phenytoin.

• Cisplatin administered with bumetanide increases ototoxicity.

• Loop diuretics like furosemide may enhance the ototoxic and nephrotoxic effects of cisplatin.

• There is no reported drug-drug interaction between cisplatin and acetaminophen.

• There is no reported drug-drug interaction between cisplatin and meperidine (Demerol).

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