•Ceftriaxone, and other cephalosporin antibiotics, can cause neurotoxicity. Seizures, confusion, twitching, and somnolence are the most common clinical manifestations. Discontinuation of the drug usually resolves the neurotoxicity.
•Renal impairment puts a patient at greater risk for cephalosporin induced neurotoxicity.
•Nausea and diarrhea can occur with Ceftriaxone, but are not severe side effects.
•Arrhythmias are not associated with the administration of Ceftriaxone.