Explanation
• Spironolactone is a potassium-sparing diuretic that can cause hyperkalemia, potentially resulting in cardiac arrhythmias
• Severe hypocalcemia and leukocytosis may cause cardiac arrhythmias, but they are not side effects of spironolactone
• Hypokalemia is associated with loop diuretics and is the opposite of what would be expected for a side effect of spironolactone